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KMID : 0379120110390030194
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Korean Journal of Mycology
2011 Volume.39 No. 3 p.194 ~ p.197
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Screening New Antihypertensive Angiotensin I-Converting Enzyme Inhibitor -Producing Yeast and Optimization of Productin Condition
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Kang Min-Gu
Kim Ha-Kun
Yi Sung-Hun
Lim Seong-Il
Lee Jong-Soo
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Abstract
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Forty eight strains of yeast were cultured in potato dextorse(PD) broth at 30oC for 24 hr and centrifuged with 12,000 rpm for 20 min. After concentrated the cultures, antihypertensive angiotensin I-converting enzyme(ACE) inhibitory activities of its concentrates were investigated. Among them, the concentrates from Saccharomyces cerevisiae Y183-3 showed the highest ACE inhibitory activity of 71.8%. The ACE inhibitor from Saccharomyces cerevisiae Y183-3 was maximally produced when Saccharomyces cerevisiae Y183-3 cultured in PD broth at 30oC for 36 hr
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KEYWORD
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Antihypertensive angiotensin I-converting enzyme inhibitor, Potato dextrose broth, Saccharomyces cerevisiae Y183-3
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